Therapeutic compounds and methods

A compound of formula (I):

• or a prodrug thereof, or a pharmaceutically acceptable salt thereof, wherein:
• R1 is —NRaRb or a 5-10 membered heteroaryl that is optionally substituted with one or more groups Rc;
• R2 is a 6-10 membered aryl that is optionally substituted with one or more groups Rr;
• or R2 is a 5-10 membered heteroaryl that is that is optionally substituted with one or more groups Rs;
• or R2 is a 3-10 membered heterocycle that is that is optionally substituted with one or more groups Rz;
• Ra is (C1-C6)alkyl, (C3-C6)cycloalkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, (C1-C6)alkanoyl, (C3-C6)cycloalkyl(C1-C6)alkyl, (C2-C6)alkynylcarbonyl, 3-6 membered heterocycle, or a 5-6 membered heteroaryl that is optionally substituted with one or more groups Rf;
• wherein each (C1-C6)alkyl, (C3-C6)cycloalkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, (C1-C6)alkanoyl, (C3-C6)cycloalkyl(C1-C6)alkyl, (C2-C6)alkynylcarbonyl, and 3-6 membered heterocycle is optionally substituted with one or more groups independently selected from the group consisting of halo, hydroxy, cyano, (C2-C6)alkenyl, (C2-C6)alkynyl, C(═O)NRmRn, and (C1-C6)alkyl that is optionally substituted with one or more groups independently selected form the group consisting of halo, hydroxy, cyano, —NRmRn, and —C(═O)NRmRn;
• Rb is H or (C1-C6)alkyl;
• each Rc is independently selected from the group consisting of cyano, —NRdRe, —C(═O)NRdRe, (C1-C6)alkyl, (C3-C6)cycloalkyl, (C3-C6)cycloalkyl(C1-C6)alkyl, (C1-C6)alkoxy, and (C1-C6)alkanoyl, wherein each (C1-C6)alkyl, (C3-C6)cycloalkyl, (C3-C6)cycloalkyl(C1-C6)alkyl, (C1-C6)alkoxy and (C1-C6)alkanoyl is optionally substituted with one or more groups independently selected from the group consisting of halo, hydroxy, carboxy, and cyano;
• Rd and Re are each independently selected from the group consisting of H and (C1-C6)alkyl;
• or Rd and Re are taken together with the nitrogen to which they are attached form a 3-6 membered heterocyclic ring that is optionally substituted with one or more groups independently selected from the group consisting of halo and (C1-C6)alkyl;
• each Rf is independently selected from the group consisting of halo, hydroxy, cyano, —NRgRh, —C(═O)NRgRh, and (C1-C6)alkyl that is optionally substituted with one or more groups independently selected from the group consisting of halo, hydroxy, carboxy, —NRgRh, —C(═O)NRgRh, and cyano;
• Rg and Rh are each independently selected from the group consisting of H and (C1-C6)alkyl;
• or Rg and Rh taken together with the nitrogen to which they are attached form a 3-6 membered heterocyclic ring that is optionally substituted with one or more groups independently selected from the group consisting of halo and (C1-C6)alkyl;
• Rm is H or (C1-C6)alkyl that is optionally substituted with one or more groups independently selected from the group consisting of halo, hydroxy, carboxy, cyano, and oxo;
• Rn is H or (C1-C6)alkyl that is optionally substituted with one or more groups independently selected from the group consisting of halo, hydroxy, carboxy, cyano, and oxo;
• each Rr is independently selected from the group consisting of halo, hydroxy, cyano, —NRtRu, —C(═O)NRtRu, —S(O)2NRtRu, (C1-C6)alkyl, (C3-C6)cycloalkyl, (C1-C6)alkoxy, (C1-C6)alkylthio, —N(H)S(O)2Rx, —S(O)2Rx, (C2-C6)alkenyl, and (C2-C6)alkynyl, wherein each (C1-C6)alkyl, (C3-C6)cycloalkyl, (C1-C6)alkoxy, (C1-C6)alkylthio, (C2-C6)alkenyl, and (C2-C6)alkynyl is optionally substituted with one or more groups independently selected from the group consisting of halo, hydroxy, carboxy, —NRtRu, —C(═O)NRtRu, —S(O)2NRtRu, —S(O)2Rx, and cyano;
• each Rs is independently selected from the group consisting of halo, cyano, —NRvRw, —C(═O)NRvRw, —S(O)2NRvRw, (C1-C6)alkyl, (C3-C6)cycloalkyl, (C1-C6)alkoxy, (C1-C6)alkanoyl, (C1-C6)alkylthio, 3-6 membered heterocycle, and —S(O)2Ry, wherein each (C1-C6)alkyl, (C3-C6)cycloalkyl, (C1-C6)alkoxy, (C1-C6)alkanoyl, 3-6 membered heterocycle, and (C1-C6)alkylthio, is optionally substituted with one or more groups independently selected from the group consisting of halo, hydroxy, carboxy, —NRtRu, —C(═O)NRtRu, S(O)2NRvRw, —S(O)2Ry, and cyano;
• Rt and Ru are each independently selected from the group consisting of H, (C1-C6)alkyl, (C1-C6)alkanoyl, and (C2-C6)alkynylcarbonyl;
• or Rt and Ru taken together with the nitrogen to which they are attached form a 3-6 membered heterocyclic ring that is optionally substituted with one or more groups independently selected from the group consisting of halo and (C1-C6)alkyl;
• Rv and Rw are each independently selected from the group consisting of H, (C1-C6)alkyl, and (C1-C6)alkanoyl;
• or Rv and Rw taken together with the nitrogen to which they are attached form a 3-6 membered heterocyclic ring that is optionally substituted with one or more groups independently selected from the group consisting of halo and (C1-C6)alkyl;
• Rx is H or (C1-C6)alkyl that is optionally substituted with one or more groups independently selected from the group consisting of halo, hydroxy, carboxy, cyano, and oxo;
• Ry is H or (C1-C6)alkyl that is optionally substituted with one or more groups independently selected from the group consisting of halo, hydroxy, carboxy, cyano, and oxo;
• and
• each Rz is independently selected from the group consisting of oxo, halo, hydroxy, and (C1-C6)alkyl that is optionally substituted with one or more groups independently selected from the group consisting of halo, hydroxy, carboxy, —NRtRu, —C(═O)NRtRu, S(O)2NRvRw, —S(O)2Ry, cyano, and oxo;
• provided the compound is not: