9H-pyrrolo-dipyridine derivatives

A compound of general formula I-A, or a pharmaceutically acceptable acid addition salt, a racemic mixture or its corresponding enantiomer and/or optical isomers thereof,

• wherein
• R1 is pyrazole, thiazole, pyridine, or pyrimidine each of which is optionally substituted by one or two substituents independently selected from (1) fluorine;
• (2) methyl, ethyl or propyl, each of which is optionally substituted by fluorine or methoxy;
• (3) cyano;
• (4) amino optionally substituted by methyl or fluoro-ethyl;
• (5) —C(O)NHR1A where R1A is methyl, ethyl, or propyl, each of which is optionally substituted by fluorine or methoxy;
• (6) methoxy, ethoxy or propoxy, each of which is optionally substituted by fluorine or methoxy;
• or (7) morpholine, piperazine or piperidine, each of which is optionally substituted by fluorine or fluoromethyl;
• M is C—R3, and Q is CH;
• or M is CH, and Q is CR3;
• R3 is (1) H;
• (2) fluorine;
• (3) methyl, ethyl or propyl, each of which is optionally substituted by fluorine, hydroxy or methoxy;
• (4) methoxy, ethoxy or propoxy, each of which is optionally substituted by fluorine, hydroxyl or methoxy;
• (4) di-methyl-amino;
• or (5) —NHR3A where R3A is methyl, ethyl or propyl, each of which is optionally substituted by fluorine, hydroxy or methoxy;
• and
• wherein
• any hydrogen of formula I-A is H, 2H or 3H;
• any carbon of formula I-A is C, 14C or 11C;
• and
• any fluorine of formula I-A is F or 18F;
• provided that the compound of formula I is not a compound of general formula Ro I
• wherein
• R is hydrogen or tritium;
• F is fluoro or 18fluoro;
• or a pharmaceutically acceptable acid addition salt thereof.