US 12,006,283 B2 · HIF-1α inhibitor, preparation method therefor, and pharmaceutical composition for preventing or treating angiogenesis-associated eye disease, containing same as active ingredient

Abstract

Disclosed are a novel hypoxia-inducible factor 1α (HIF-1α) inhibitor, a method of preparing the same, and a pharmaceutical composition for preventing or treating an angiogenesis-related eye disease containing the same as an active ingredient. The compound of Example provided according to an embodiment of the present invention is capable of effectively inhibiting HIF-1α and is thus useful as a pharmaceutical composition for preventing or treating an angiogenesis-related eye disease.

Claims5

Dependent claims

A compound represented by the following Formula (1), or a solvate, hydrate, optical isomer or pharmaceutically acceptable salt thereof:

A1 and A2 are methoxy or A1 is H and A2 is F;
B1 is —H, or C1-10 straight- or branched-chain alkoxy;
and
R1 is C3-10 cycloalkyloxy, heterocycloalkyl of a 5- to 10-membered ring containing at least one heteroatom selected from the group consisting of N, O and S, or benzylamino unsubstituted or substituted with —CN.

1 more element

Dependencies are inferred from the claim text.

Facts

Application

17/057,297Filed 12 Aug 2019

Priority

KR 10-2018-010398531 Aug 2018

Published

US 2021/0188753 A124 Jun 2021

Granted

11 Jun 2024

Term ends

Not estimatedThe source records don’t support an estimate.

Classification16 codes

C07C 49/84
Ketones containing a keto group bound to a six-membered aromatic ring: containing ether groups, [IMAGE cpc-sch-C07C-0958.gif] groups,[IMAGE…
A61K 31/12
Medicinal preparations containing organic active ingredients: ketones
A61P 27/02
Drugs for disorders of the senses: ophthalmic agents
C07C 225/22
Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms…:…

HIF-1α inhibitor, preparation method therefor, and pharmaceutical composition for preventing or treating angiogenesis-associated eye disease, containing same as active ingredient

Life of this patent

HIF-1α inhibitor, preparation method therefor, and pharmaceutical composition for preventing or treating angiogenesis-associated eye disease, containing same as active ingredient

Life of this patent

Abstract

Claims5