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US 12,006,085 B2Granted
Fill-finish process for peptide solutions
Assignee3-D Matrix, Ltd.
InventorsMasahiro Nohara, Yuya Hasegawa
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Abstract
The enclosed disclosure describes, among other things, a method including the steps of a first deaerating step in which a mixture comprising peptides is deaerated by lowering the pressure, filtering the mixture through a sterilizing filter; and a second deaerating step, in which the filtrate is deaerated by vibration and lowering the pressure.
Claims15
A method for deaerating and sterilizing a self-assembling peptide solution having at least 0.5 weight % of a self-assembling peptide, the method comprising the steps of:
- a first deaerating step wherein the self-assembling peptide solution is deaerated by lowering a pressure on the self-assembling peptide solution to vacuum;
- filtering the self-assembling peptide solution through a sterilizing filter thereby producing a self-assembling peptide filtrate;
- and
- a second deaerating step wherein the filtrate is deaerated by vibration at a vibration frequency between 20 and 360 revolutions per minute, and by lowering the pressure on the self-assembling peptide filtrate by at least 0.05 MPa.
1 more element
Dependencies are inferred from the claim text.