Apparatus and method for bio-particle detection

An apparatus for bio-particle detection, the apparatus comprising:

• a first main body comprising a sample solution inlet and a sample solution outlet;
• a second main body structurally connected to the first main body and configured to allow a fluid to flow;
• a bio-particle detection chip provided between the first main body and the second main body, the bio-particle detection chip comprising a substrate having a plurality of through-hole groups, each through-hole group of the plurality of through-hole groups including through-holes which pass through the substrate from a first surface of the substrate toward an second surface of the substrate opposite to the first surface, and which are configured to accommodate a sample solution loaded therein;
• channels provided between the first main body and the second main body, and configured to have a sample solution flow therethrough;
• and
• a processor configured to determine a number of through-holes, among the through holes of at least one through-hole group of the plurality of through-hole groups, having a target material encapsulated therein, based on at least one of an electrical signal and an optical signal corresponding to the through-holes of the at least one through-hole group, and estimate a concentration of the target material based on the determined number;
• wherein the through-holes of each through-hole group of the plurality of through-hole groups have at least one of diameters, volumes, shapes, or arrangement interval different than respective diameters, volumes, shapes, or arrangement interval of the through-holes of other through-hole groups of the plurality of through-hole groups.