US 12,005,383 B2Granted

Method for fluorinating a filter for a pipette tip, pipette tip, associated production method and pipette

AssigneesGilson, Inc., Universite Clermont Auvergne, Sigma Clermont, Centre National de la Recherche

InventorsNicolas Batisse, Marc Dubois, Jérémy Peyroux, Béatrice Guieu Presle

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Abstract

A method for fluorinating a filter for a pipette tip, the filter being made of a solid porous structure made of polyolefin. The method comprises the following steps: (a) placing the filter in an enclosure, (b) creating a vacuum in the enclosure, and (c) bringing the filter into contact with a fluorination agent injected into the enclosure in a gaseous state, the fluorination agent being made up of difluorine F2, the difluorine F2 being injected into the enclosure at a partial pressure between 100 Pa and 10000 Pa and step (c) being done at a temperature between 0° C. and 100° C. A pipette tip comprising a filter modified by the fluorination method, a method for producing such a tip, as well as a withdrawing pipette equipped with such a tip.

Claims22

Dependent claims

Method for fluorinating a filter for a pipette tip, this filter being formed by a porous solid polyolefin structure, characterized in that it comprises the following steps:

(a) placing the filter in an enclosure,
(b) creating a vacuum in the enclosure, and
(c) contacting the filter with a fluorination agent introduced in the gaseous state into the enclosure,
in that the fluorination agent consists of difluorine F2, in that the difluorine F2 is introduced into the enclosure at a partial pressure between 100 Pa and 10000 Pa, in that step (c) is conducted at a temperature between 0° C. and 100° C., and further comprising after step (c):
(e1) creating a vacuum in the enclosure, followed by
(e2) contacting the filter with dihydrogen or a mixture comprising dihydrogen, the dihydrogen or mixture comprising dihydrogen comprising dihydrogen being introduced in the gaseous state into the enclosure.

3 more elements

Dependencies are inferred from the claim text.

Facts

Application: 16/969,288Filed 18 Feb 2019
Priority: FR 185144120 Feb 2018
Published: US 2021/0008478 A114 Jan 2021
Granted: 11 Jun 2024
Term ends: Not estimatedThe source records don’t support an estimate.

Classification10 codes

B01D 39/1653
The material being particulate: of synthetic origin
B01D 39/1692
Of organic material, e.g. synthetic fibres: other shaped material, e.g. perforated or porous sheets
B01L 3/0217
Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids: of the plunger pump type
C08L 23/283
By reaction with halogens or halogen-containing compounds: iso-olefin halogenated homopolymers or copolymers

Family

US 2021/0008478 A1Pre-grant publication · published 14 Jan 2021
US 12,005,383 B2This patent

From the US filing history. Foreign family members aren’t listed.

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