Direct drug/therapeutic infusion via trans-vascular glymphatic system and method

A dopamine or other drug/therapeutics delivery and monitoring system for treatment of brain disease comprising:

• a. an implantable titrator operatively connected to one or more selected regions of the brain via the glymphatic system comprising:
• a micropump for controlled pumping of dopamine into the one or more regions of the brain responsive to dopamine levels in the withdrawn CSF in the region of the brain that are monitored by a dopamine sensor in the implantable titrator;
• and
• a mixing chamber in the implantable titrator to combine withdrawn CSF with dopamine from a reservoir in the titrator to form a mixture for controlled delivery of the mixture into the brain region;
• b. at least one microtube comprising a needle of a memory alloy having a straight and curved phase deployed through an arterial blood vessel of a vascular system connected to the titrator configured for delivery of dopamine or other drug/therapeutics through the vessel wall into the glymphatic system and thence into the one or more selected regions of the brain;
• c. a second microtube operably connected to the titrator for withdrawal of CSF from the one or more regions of the elymphatic system;
• and
• d. a fiber optic implanted into the brain region for sensing dopamine levels in the elymphatic system.

A dopamine delivery and monitoring system for treatment of brain disease comprising:

• a. an implantable titrator in a human operatively connected to one or more selected regions of the brain via the glymphatic system and further comprising;
• a micropump for controlled pumping of dopamine into the one or more regions of the brain responsive to dopamine levels in the withdrawn CSF in the region of the brain that are monitored by a dopamine sensor in the implantable titrator;
• a reservoir for storage of dopamine in the implantable titrator;
• and
• a mixing chamber in the implantable titrator to combine withdrawn CSF with dopamine from the reservoir in the titrator to form a mixture for controlled delivery of the mixture into the brain region via the glymphatic system;
• b. at least one microtube connected to the titrator for delivery of dopamine through a cerebral artery for diffusion to one or more selected regions of the brain via the glymphatic system;
• and
• c. a second microtube operably connected to the titrator for withdrawal through a microtube of CSF from the one or more regions of the glymphatic system in the brain.