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US 12,005,220 B2Granted
Microneedle patch for immunostimulatory drug delivery
AssigneeVeradermics Incorporated
InventorsReid Waldman, Madeline DeWane, Ming Hua Lee, Lauren Sweeney Durso
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Abstract
The application provides a dissolvable microneedle device to deliver immune stimulants to the skin. The application also provides a method of treating a skin condition comprising applying a dissolvable microneedle device to the skin.
Claims30
A dissolvable microneedle patch for delivery of a therapeutically active ingredient to skin comprising:
- a plurality of microneedles and a removable substrate;
- wherein the plurality of microneedles are attached to the removable substrate;
- wherein the plurality of microneedles comprise a tapered tip that extends away from the removable substrate;
- wherein the plurality of microneedles comprise a biodegradable polymer and a therapeutically active ingredient dispersed in the biodegradable polymer;
- and
- wherein the therapeutically active ingredient is an immunogenic stimulator selected from the group consisting of Candida antigen, trichophyton antigen, and tuberculin;
- and
- wherein the immunogenic stimulator is substantially free of glycerin.
5 more elements
A method of treating a skin condition comprising:
- applying a dissolvable microneedle patch for delivery of a therapeutically active ingredient to skin comprising:
- a plurality of microneedles and a removable substrate;
- wherein the plurality of microneedles are attached to the removable substrate;
- wherein the plurality of microneedles comprise a tapered tip that extends away from the removable substrate;
- wherein the plurality of microneedles comprise a biodegradable polymer and a therapeutically active ingredient dispersed in the biodegradable polymer;
- wherein the therapeutically active ingredient is an immunogenic stimulator selected from the group consisting of Candida antigen, trichophyton antigen, and tuberculin;
- and
- wherein the immunogenic stimulator is substantially free of glycerin;
- exerting sufficient force on the dissolvable microneedle patch to permit the plurality of microneedles to penetrate to a location selected from the group consisting of epidermis, dermis, and papillary dermis;
- allowing the plurality of microneedles to remain in the skin until the biodegradable polymer degrades;
- and
- removing an adhesive substrate from the dissolvable microneedle patch.
9 more elements
Dependencies are inferred from the claim text.