Drug-coated balloon catheters for body lumens

A method for treatment of or reduction of the occurrence of an anastomotic non-vascular stricture, the method comprising:

• inserting a balloon catheter into a target site in a body lumen comprising the anastomotic non-vascular stricture, wherein the anastomotic non-vascular stricture comprises a stricture in an anastomosis between two portions of the same body structure, or between two different body structures, wherein the balloon catheter comprises
• an elongated balloon, and
• a coating layer overlying an exterior surface of the balloon, wherein the coating layer comprises an initial drug load of a therapeutic agent;
• inflating the balloon at the target site to contact the coating layer with walls of the body lumen at the location of the anastomotic non-vascular stricture until the balloon achieves an inflated balloon diameter for an inflation period;
• deflating the balloon after the inflation period;
• and
• withdrawing the balloon catheter from the body lumen;
• wherein the balloon catheter provided in the target site is a soaked balloon catheter, wherein the balloon catheter is soaked outside the body with a soaking solution comprising water or saline, or the balloon catheter is soaked in the target site with a flushing solution comprising water or saline, or a combination thereof;
• and
• wherein
• the anastomotic non-vascular stricture comprises an esophageal stricture, stomach stricture, small intestine stricture, duodenum stricture, jejunum stricture, ileum stricture, colon stricture, rectum stricture, large intestine stricture, colorectal stricture, a stricture after gastric bypass, ileocolonic stricture, gastrointestinal stricture, urethral stricture, ureteral stricture, J-pouch stricture, or a bladder neck stricture, or
• the body structure or two different body structures comprise an esophagus, stomach, small intestine, duodenum, jejunum, ileum, colon, rectum, large intestine, colon, rectum, urethra, ureter, or bladder neck, or
• a combination thereof.

A method for treatment of or reduction of the occurrence of an anastomotic non-vascular stricture, the method comprising:

• inserting a balloon catheter into a target site in a body lumen comprising the anastomotic non-vascular stricture, wherein the anastomotic non-vascular stricture comprises a stricture in an anastomosis between two portions of the same body structure, or between two different body structures, wherein the balloon catheter comprises
• an elongated balloon, and
• a coating layer overlying an exterior surface of the balloon, wherein the coating layer comprises an initial drug load of a therapeutic agent chosen from paclitaxel, docetaxel, taxol, rapamycin, sirolimus, zotarolimus, everolimus, tacrolimus, mTOR inhibitors, analogues thereof, and combinations thereof;
• inflating the balloon at the target site to contact the coating layer with walls of the body lumen at the location of the anastomotic non-vascular stricture until the balloon achieves an inflated balloon diameter for an inflation period;
• deflating the balloon after the inflation period;
• and
• withdrawing the balloon catheter from the body lumen;
• wherein the balloon catheter provided in the target site is a soaked balloon catheter, wherein the balloon catheter is soaked outside the body with a soaking solution comprising water or saline, or the balloon catheter is soaked in the target site with a flushing solution comprising water or saline, or a combination thereof;
• and
• wherein
• the anastomotic non-vascular stricture comprises an esophageal stricture, stomach stricture, small intestine stricture, duodenum stricture, jejunum stricture, ileum stricture, colon stricture, rectum stricture, large intestine stricture, colorectal stricture, a stricture after gastric bypass, ileocolonic stricture, gastrointestinal stricture, urethral stricture, ureteral stricture, J-pouch stricture, or a bladder neck stricture, or
• the body structure or two different body structures comprise an esophagus, stomach, small intestine, duodenum, jejunum, ileum, colon, rectum, large intestine, colon, rectum, urethra, ureter, or bladder neck, or
• a combination thereof.