Extracorporeal circuit and column design therefore

A method of removing one or more components present in bodily fluid to produce a decontaminated bodily fluid, the method comprising:

• attaching a cartridge to an input for bodily fluid;
• attaching the cartridge to an output for a decontaminated bodily fluid from the cartridge;
• passing bodily fluid through the cartridge, wherein the cartridge comprises:
• a cartridge body configured to retain an adsorptive material;
• and
• an end segment configured to cover a first end of the cartridge body, the end segment comprising:
• a circular face comprising an outwardly truncated conical shape and defining an internal conical space;
• a cylindrical wall joined to a periphery of the circular face;
• and
• an inlet configured to provide fluid connection to a source of the bodily fluid, wherein the inlet comprises a central axis that is perpendicular to a longitudinal axis of the end segment, wherein the inlet is (1) disposed tangential to the circular face at the cylindrical wall so as to (i) direct bodily fluid entering the cartridge into the internal conical space tangentially so as to decelerate the bodily fluid within the internal conical space prior to contact with the adsorptive material disposed within the cartridge body, and (ii) cause the bodily fluid to enter the cartridge substantially perpendicular to a flow direction of the bodily fluid through the adsorptive material and (2) configured to utilize gravity to assist the bodily fluid with contacting the adsorptive material;
• and
• filtering one or more substances from the bodily fluid to produce the decontaminated bodily fluid.