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AssigneeUniversity of Pittsburgh—Of the Commonwealth System of Higher Education
InventorsStephen F. Badylak, Timothy Joseph Keane, Jr., Neill Jordon Turner, Christopher Lee Dearth
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Provided are methods for preparing sterilized, gelled, solubilized extracellular matrix (ECM) compositions useful as cell growth substrates. Also provided are compositions prepared according to the methods as well as uses for the compositions. In one embodiment a device, such as a prosthesis, is provided which comprises an inorganic matrix into which the gelled, solubilized ECM is dispersed to facilitate in-growth of cells into the ECM and thus adaptation and/or attachment of the device to a patient.
A gelable extracellular matrix (ECM) composition comprising a decellularized, enzymatically digested, dried, electron-beam sterilized, intact extracellular matrix, wherein said composition is capable of forming a gel upon hydration, neutralization to pH 7.2-7.8, and warming to a temperature greater than 25° C.
A method of preparing an extracellular matrix-derived gelable composition comprising, in order:
Dependencies are inferred from the claim text.