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US 12,005,157 B2Granted
Isolation and co-transplantation of bone marrow mesenchymal stem cells with CD34+ hematopoietic stem/progenitor cells
AssigneesNorthwestern University, Ann & Robert H. Lurie Children's Hospital of Chicago
InventorsArun Sharma, Natalie J. Fuller, Matthew I. Bury, Earl Y. Cheng
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Abstract
Provided herein are populations of bone marrow mesenchymal stem cells (MSCs) and CD34+ hematopoietic stem/progenitor cells (HSPCs), and methods of isolation and co-administration thereof. In particular, cell populations and methods of co-administration thereof are provided for enhancing tissue (e.g., bladder) regeneration.
Claims10
A system comprising:
- (a) a synthetic elastomeric scaffold for supporting and transplantation of cells,
- (b) a cell population of isolated mesenchymal stem cells (MSCs), wherein greater than 90% of the MSCs are CD29+, CD44+, CD73+, CD90+, CD105+, CD166+, CD14−, CD34−, CD45−, CD117−, and CD133−;
- and
- (c) a cell population of hematopoietic stem/progenitor cells (HSPCs), wherein greater than 90% of the HSPCs are CD34+.
1 more element
An article of manufacture comprising:
- a cell scaffold configured to be inserted into a subject, wherein said cell scaffold is impregnated with:
- (a) a cell population of isolated mesenchymal stem cells (MSCs), wherein greater than 90% of the MSCs are CD29+, CD44+, CD73+, CD90+, CD105+, CD166+, CD14−, CD34−, CD45−, CD117−, and CD133−;
- and
- (b) a cell population of hematopoietic stem/progenitor cells (HSPCs), wherein greater than 90% of the HSPCs are CD34+.
1 more element
Dependencies are inferred from the claim text.