Microgel composition comprising collagen and method of preparing the same
AssigneeKorea Institute of Science and Technology
InventorsSang-Heon Kim, Seung Ja Oh, Ha Eun Chung
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Abstract
The present disclosure relates to a microgel composition comprising collagen and hyaluronic acid and a method of preparing the same. The microgel according to an embodiment is composed of natural biocompatible substances and is non-toxic and has high mechanical stability or long persistence, and thus can be effectively used in a microgel composition, a three-dimensional scaffold composition, and a tissue-engineering scaffold.
Claims8
A microgel composition comprising 10% (w/v) of collagen and 2.5% (w/v) to 5% (w/v) of hyaluronic acid,
- wherein the composition has a zeta potential of −50 mV to −30 mV,
- wherein the composition has a pH of 4 to 11, and
- wherein the microgel is in the form of a nonwoven fabric;
- a woven fabric;
- a knitted fabric;
- a fiber bundle;
- a cylinder including a fiber bundle and a tube into which the fiber bundle is inserted;
- or a combination of two or more thereof.
A three-dimensional scaffold comprising 10% (w/v) of collagen and 2.5% (w/v) to 5% (w/v) of hyaluronic acid,
- wherein the scaffold has a zeta potential of −50 mV to −30 mV, and
- wherein the scaffold is in the form of a nonwoven fabric;
- a woven fabric;
- a knitted fabric;
- a fiber bundle;
- a cylinder including a fiber bundle and a tube into which the fiber bundle is inserted;
- or a combination of two or more thereof.
A scaffold for tissue engineering, comprising 10% (w/v) of collagen and 2.5% (w/v) to 5% (w/v) of hyaluronic acid,
- wherein the scaffold has a zeta potential of −50 mV to −30 mV, and
- wherein the scaffold is in the form of a nonwoven fabric;
- a woven fabric;
- a knitted fabric;
- a fiber bundle;
- a cylinder including a fiber bundle and a tube into which the fiber bundle is inserted;
- or a combination of two or more thereof.
A method of preparing a microgel composition, the method comprising:
- forming an electrostatic collagen-hyaluronic acid complex by reacting 10% (w/v) of collagen and 2.5% (w/v) to 5% (w/v) of hyaluronic acid;
- preparing a dispersion of a microgel by breaking the collagen-hyaluronic acid complex;
- and adjusting pH level of the dispersion to 4-11,
- subjecting the dispersion of the microgel to natural sedimentation,
- wherein the composition has a zeta potential of −50 mV to −30 mV, and
- wherein the microgel is in the form of a nonwoven fabric;
- a woven fabric;
- a knitted fabric;
- a fiber bundle;
- a cylinder including a fiber bundle and a tube into which the fiber bundle is inserted;
- or a combination of two or more thereof.
Dependencies are inferred from the claim text.