Back to results
US 12,005,142 B2Granted
Sustained-release compositions comprising a therapeutic agent for treating depression or anxiety and uses thereof
OwnerKeelung Hong, Yi-Yu Lin +1inventors
InventorsKeelung Hong, Yi-Yu Lin, Hao-Wen Kao
Life of this patent
Estimating the term…
Abstract
The present invention relates to a pharmaceutical composition comprising at least one liposome and a therapeutic agent for treating depression or anxiety, with a therapeutic agent to lipid ratio equal to or higher than about 0.15. The pharmaceutical composition improves the pharmacokinetic profile and sustains the release of the therapeutic agent. Also provided is the method for treating depression or anxiety using the pharmaceutical composition disclosed herein.
Claims20
A pharmaceutical composition, comprising
- (a) at least one liposome comprising a bilayer membrane, said bilayer membrane comprises a first lipid that is HSPC, DMPC or any combination thereof, cholesterol and a second lipid that is PEG-DSPE;
- (b) a trapping agent that is triethylammonium sucrose octasulfate, ammonium sulfate, or any combination thereof;
- and
- (c) a therapeutic agent that is ketamine,
- wherein the molar ratio of the therapeutic agent to the lipid is equal to or higher than about 0.2, the therapeutic agent is encapsulated in the liposomes with an encapsulation efficiency higher than about 60% and the mean particle size of the liposome is from about 50 nm to about 20 μm.
2 more elements
A pharmaceutical composition, comprising
- (a) at least one liposome comprising a bilayer membrane, said bilayer membrane comprises a first lipid that is HSPC, DPPC or any combination thereof, cholesterol and optionally a second lipid that is PEG-DSPE, DPPG or any combination thereof;
- (b) a trapping agent that is 10 to 200 mM triethylammonium sucrose octasulfate, 300 to 600 mM ammonium sulfate, 100 to 600 mM ammonium phosphate or any combination thereof;
- and
- (c) a therapeutic agent that is scopolamine,
- wherein the molar ratio of the therapeutic agent to the lipid is equal to or higher than about 0.15, the therapeutic agent is encapsulated in the liposomes with an encapsulation efficiency higher than about 60% and the mean particle size of the liposome is from about 50 nm to about 20 μm.
2 more elements
Dependencies are inferred from the claim text.