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US 12,005,128 B1Granted
Near infrared small molecule probes for the detection of cellular senescence
AssigneeUNM Rainforest Innovations
InventorsLina Cui, Jun Liu, Xiaowei Ma, Ying Wang, Philip Deenik
Life of this patent
Estimating the term…
Abstract
A probe comprising a biomarker-triggered moiety, a near infrared (NIR) fluorophore reporter, a self-immolative linker and a self-immobilizing moiety for visualization of senescent cells and methods of use thereof.
Claims3
A probe for visualization of senescent cells wherein the probe has the chemical structure:
- where R is CHF2.
A method for detecting or visualizing cell senescence comprising delivering to one or more cells a senescence visualizing probe having the chemical structure:
- where R is CHF2.
Dependencies are inferred from the claim text.