Nanoparticles for use in photodynamic therapies and methods of making, evaluating and using the same
AssigneeMi2 Holdings LLC
InventorsAndrew Hopkins, Thomas Hopkins
Life of this patent
Estimating the term…
Abstract
A nanocomposition for use in treating cardiac, oncologic, bariatric, or dermatologic indications, conditions and diseases condition using phthalocyanine dye, such as IR700. A nanocomposition having IR700, an 8PEG nanoparticle and a RGD, or iRGD targeting agent. Administering a product comprising IR700 to a patient, whereby the IR700 is delivered to the target tissue, and found in only target tissue; and administering light to activate the IR700, thereby producing an ROS.
Claims19
A composition comprising:
- a plurality of nanoparticles, the nanoparticles comprising an 8-arm PEG core;
- wherein the 8-arm PEG core is substituted with at least a photosensitizer (PS) and a targeting agent (TA) that are directly linked to the 8-arm PEG core;
- wherein at least three arms of the 8-arm PEG core are unsubstituted;
- wherein the 8-arm PEG core contains 1-2 PS per 8-arm PEG core;
- and
- wherein the 8-arm PEG core has a weight of at least about 40 kDa.
A method of Photodynamic treatment of a medical cardiac, oncologic, bariatric, or dermatologic condition in a subject in need thereof, the method comprising:
- Administering a composition to the subject, the composition comprising:
- a plurality of nanoparticles, the nanoparticles comprising an 8-arm PEG core;
- wherein the 8-arm PEG core is substituted with at least a photosensitizer (PS) and a targeting agent (TA) that are directly linked to the 8-arm PEG core;
- wherein at least three arms of the 8-arm PEG core are unsubstituted;
- wherein the 8-arm PEG core contains 1-2 PS;
- and
- wherein the 8-arm PEG core has a weight of at least about 40 kDa;
- Allowing a period of time for the composition to accumulate in a target tissue;
- and
- Administering light to activate the PS in the composition;
- and,
- Providing sufficient light dosage to kill the target tissue.
Dependencies are inferred from the claim text.