Vaccine molecules
AssigneeUniversity of Oslo
InventorsGunnveig Grødeland, Bjarne Bogen, Ane Marie Anderson
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Abstract
Provided herein is technology relating to vaccines and particularly, but not exclusively, to compositions, methods, and uses of a mixture of immunogenic vaccine molecules comprising components for targeting the dimeric vaccine molecules to antigen-presenting cells and components for eliciting an immunogenic response, wherein the components for eliciting an immunogenic response preferably comprise at least three variants of an immunogenic protein, such as variants of immunogenic proteins obtained from three or more different strains of a pathogenic organism.
Claims19
A DNA vaccine comprising three or more different nucleic acid constructs, each of said constructs encoding a fusion protein comprising a targeting unit, a multimerization domain, and an antigenic unit in operable association, wherein said antigenic unit for each of said three or more different nucleic acid constructs differ by encoding different variant target antigenic proteins and wherein when said three or more different nucleic acid constructs are introduced into a cells a random mixture of multimeric protein molecules comprising the same and different variant target antigenic proteins are produced via association of said multimerization domains.
Dependencies are inferred from the claim text.