Gut bacteria derived microvesicles for vaccine delivery
AssigneeQuadram Institute Bioscience
InventorsRegis Stentz, Simon Carding
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Abstract
The present invention relates to a vaccine suitable for immunisation against influenza, plague or Y. pestis infection said vaccine comprising outer membrane vesicles (OMVs) and the plague vaccine including the V and/or F1 antigens of Y. pestis.
Claims6
A mucosal vaccine delivered by oral and/or nasal administration for immunization against plague or Y. pestis infection in animals and humans wherein said vaccine comprises outer membrane vesicles (OMVs) including the V and/or F1 antigens of Y. pestis wherein the OMVs are produced by modified Bacteroides thetaiotaomicron (Bt) wherein the genes or mini-genes encoding the V and/or F1 Y. pestis antigens are cloned downstream of sequences encoding the N-terminal signal peptides of the Bt OMV protein OmpA.
Dependencies are inferred from the claim text.