Cancer vaccines for colorectal cancer
AssigneeCureVac Netherlands B.V.
InventorRonald Hans Anton Plasterk
Life of this patent
Estimating the term…
Abstract
The invention relates to the field of cancer, in particular colorectal cancer. In particular, it relates to the field of immune system directed approaches for tumor reduction and control. Some aspects of the invention relate to vaccines, vaccinations and other means of stimulating an antigen specific immune response against a tumor in individuals. Such vaccines comprise neoantigens resulting from frameshift mutations that bring out-of-frame sequences of the APC, ARID1A, KMT2D, RNF43, SOX9, TCF7L2, TP53, and ZFP36L2 genes in-frame. Such vaccines are also useful for ‘off the shelf’ use.
Claims9
A therapeutic vaccine or collection of therapeutic vaccines for treating colorectal cancer comprising:
- a peptide, or a collection of tiled peptides, having the amino acid sequence selected from SEQ ID NO:709, an amino acid sequence having 90% identity to SEQ ID NO:709, a fragment comprising at least 10 consecutive amino acids of SEQ ID NO:709, or one or more nucleic acids encoding said peptide or collection of tiled peptides;
- and
- a peptide, or a collection of tiled peptides, having the amino acid sequence selected from SEQ ID NO:710, an amino acid sequence having 90% identity to SEQ ID NO:710, a fragment comprising at least 10 consecutive amino acids of SEQ ID NO:710, or one or more nucleic acids encoding said peptide or collection of tiled peptides;
- preferably also comprising
- a peptide, or a collection of tiled peptides, having the amino acid sequence selected from SEQ ID NO:711, an amino acid sequence having 90% identity to SEQ ID NO:711, a fragment comprising at least 10 consecutive amino acids of SEQ ID NO:711, or one or more nucleic acids encoding said peptide or collection of tiled peptides;
- and/or
- a peptide, or a collection of tiled peptides, having the amino acid sequence selected from SEQ ID NO:712, an amino acid sequence having 90% identity to SEQ ID NO:712, a fragment comprising at least 10 consecutive amino acids of SEQ ID NO:712, or one or more nucleic acids encoding said peptide or collection of tiled peptides.
The therapeutic vaccine or collection of therapeutic vaccines of 2, wherein said peptides are comprised within the same polypeptide.
Dependencies are inferred from the claim text.