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US 12,005,082 B2Granted
Composition and method of use recombinant fusion protein to generate CAR-immune cells
AssigneeSingular Immune, Inc.
InventorsYoungwook Won, Seungmin Han, David Bull
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Abstract
Provided herein are a recombinant chimeric antigen receptor (CAR) fusion protein, a method of modifying an immune cell into a CAR immune cell by treating the immune cell with the recombinant CAR fusion protein, and a method of treating cancer by administering the CAR immune cell to a subject in need thereof.
Claims16
A recombinant chimeric antigen receptor (CAR) fusion protein comprising, in order:
- an immune cell targeting domain, the immune cell targeting domain being a NK cell targeting domain, or a T cell targeting domain,
- a cleavable peptide,
- a membrane targeting domain, the membrane targeting domain being a peptide from interleukin-1 receptor type 1, 4F2 cell-surface antigen heavy chain, a linker for activation of T-cells family member 1, junctophilin-1, antilisterial bacteriocin subtilosin biosynthesis protein AlbG, calcitonin receptor, gamma-secretase subunit APH-1A, or adipnectin receptor protein 2,
- an extracellular cancer targeting domain,
- a transmembrane domain, and
- an intracellular signaling domain.
3 more elements
Dependencies are inferred from the claim text.