Cobinamide compounds as a cyanide, sulfide, or methane-thiol antidote
AssigneesThe Regents of the University of California, The Regents of the University of Colorado
InventorsGerard Boss, Adriano Chan, Matthew Brenner, Sari Brenner Mahon, Vikhyat Bebarta
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Abstract
Methods and compositions for treating cyanide, sulfide, or methane-thiol exposure in a subject. The compositions may include one or more cobinamide compounds, such as an amino-tetrazole-cobinamide and/or a di-(amino-tetrazole)-cobinamide.
Claims16
A method for ameliorating one or more symptoms associated with cyanide exposure, sulfide exposure, or methane thiol exposure in a subject, comprising administering to the subject an effective amount of a pharmaceutical composition comprising an effective amount of one or more cobinamide compounds;
- wherein the one or more cobinamide compounds is selected from the group consisting of an amino-tetrazole-cobinamide, a di-(amino-tetrazole)-cobinamide, an acetyl-tetrazole-cobinamide, and a di-(acetyl-tetrazole)-cobinamide.
A pharmaceutical composition comprising one or more cobinamide compounds, wherein the one or more cobinamide compounds is selected from the group consisting of an amino-tetrazole-cobinamide, a di-(amino-tetrazole)-cobinamide, an acetyl-tetrazole-cobinamide, and a di-(acetyl-tetrazole)-cobinamide.
Dependencies are inferred from the claim text.