Nicotine tablet
AssigneeFertin Pharma A/S
InventorsBruno Provstgaard Nielsen, Kent Albin Nielsen
Life of this patent
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Abstract
The invention relates to an orally disintegrating nicotine tablet for nicotine craving relief comprising a pressed powder formulation, the tablet being designed to disintegrate within a period of less than 60 seconds upon oral administration, the powder formulation comprising an amount of nicotine and a pH regulating agent.
Claims22
An orally disintegrating nicotine tablet for nicotine craving relief comprising a pressed powder formulation, wherein the tablet disintegrates within a period of less than 210 seconds upon oral administration, wherein the pressed powder formulation comprises an amount of nicotine, a pH regulating agent, at least one polyol, and a disintegrant wherein the tablet comprises the polyol in an amount of more than 40% by weight of the tablet, wherein the tablet comprises the disintegrant in an amount of 1-10% by weight of the tablet, wherein the formulation provides a peak saliva pH of more than 7.6 during the first 120 seconds upon oral administration, wherein at least 40% by weight of the nicotine is absorbed through the oral mucosa, and wherein the tablet substantially reduces the side effect of burning.
An orally disintegrating nicotine tablet for nicotine craving relief comprising a pressed powder formulation, wherein the tablet disintegrates within a period of less than 210 seconds upon oral administration, wherein the pressed powder formulation comprises an amount of nicotine, a pH regulating agent, at least one polyol, and a disintegrant
- wherein the tablet comprises the polyol in an amount of more than 40% by weight of the tablet,
- wherein the tablet comprises the disintegrant in an amount of 1-10% by weight of the tablet,
- wherein the formulation provides a peak saliva pH of more than 7.6 during the first 120 seconds upon oral administration,
- wherein at least 40% by weight of the nicotine is absorbed through the oral mucosa, and
- wherein the tablet provides alleviation of nicotine craving within a period of no more than 300 seconds upon oral administration.
An orally disintegrating nicotine tablet for nicotine craving relief comprising a pressed powder formulation, wherein the tablet disintegrates within a period of less than 210 seconds upon oral administration, wherein the pressed powder formulation comprises an amount of nicotine, a pH regulating agent, at least one polyol, and a disintegrant wherein the tablet comprises the polyol in an amount of more than 40% by weight of the tablet, wherein the tablet comprises the disintegrant in an amount of 1-10% by weight of the tablet, wherein the formulation provides a peak saliva pH of more than 7.6, wherein at least 40% by weight of the nicotine is absorbed through the oral mucosa, and wherein the tablet reduces the side effect of burning.
Dependencies are inferred from the claim text.