Methods for preventing or treating H. pylori infection

A method for treating, ameliorating, and/or reversing a Helicobacter pylori (H. pylori) infection in a patient in need thereof, comprising administering to said patient:

• an effective amount of compound I 4-Deoxy-3,4-(1H)-imidazo-(2,5-dihydro)rifamycin, or a pharmaceutically acceptable salt thereof;
• an effective amount of an additional antibiotic, and an effective amount of an acid blocker,
• wherein said compound I is administered to said patient at a dose of about 400 mg to about 600 mg, twice per day (BID) or three times per day (TID),
• wherein said compound I is a compound of Formula 2
• wherein an effective amount of said acid blocker is at a dose of about 10 mg to about 20 mg, and said acid blocker is proton pump inhibitor (PPI);
• and,
• wherein an effective amount of said additional antibiotic is twice per day (BID) or three times per day (TID), for 7-14 consecutive days;
• and said additional antibiotic is amoxicillin.