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US 12,005,037 B2Granted
Formulations containing expectorants or decongestants
OwnerMinh Tran, Yi Zeng +3inventors
InventorsMinh Tran, Yi Zeng, Zhang Julia Zhang, Hengsheng Feng, Dahai Guo
Life of this patent
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Abstract
The present invention relates to bioavailable fill compositions containing one or more of a decongestant, an expectorant, an antitussive, an analgesic, and/or an antihistamine; capsules filled with the bioavailable fill compositions; and methods of making same.
Claims6
A clear bioavailable liquid composition comprising:
- (a) active ingredients selected from the group consisting of:
- (i) from 22 wt % to 25 wt % of guaifenesin and from 0.5 wt % to 0.7 wt % of phenylephrine HCl;
- (ii) from 22 wt % to 25 wt % of guaifenesin and from 1 wt % to 2 wt % of dextromethorphan HBr;
- (iii) from 21 wt % to 24 wt % of guaifenesin, from 0.4 wt % to 1 wt % of phenylephrine HCl, and from 1 wt % to 2 wt % of dextromethorphan HBr;
- or
- (iv) from 21 wt % to 25 wt % of guaifenesin and from 2 wt % to 5 wt % of pseudoephedrine HCl;
- (b) a matrix comprising:
- 20-70 wt % of a pharmaceutically acceptable poly(alkylene glycol), and
- 0.5-8 wt % of a pharmaceutically acceptable alkylene glycol;
- and
- (c) a polymeric solubilizing agent consisting of 1-30 wt % of polyvinylpyrrolidone;
- and
- (d) 1-10 wt % of water;
- wherein the wt % values are based on the total weight of the composition, and
- wherein the liquid composition remains clear without recrystallization for up to 2 years at room temperature.
12 more elements
Dependencies are inferred from the claim text.