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US 12,005,035 B1Granted
Compositions and methods for treatment of chronic pain and depression
OwnerDaniel C. Javittinventor
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Abstract
Described herein is a composition that includes an N-methyl-D-aspartate receptor (NMDAR) antagonist and a TAS2R receptor response mediating agent for treating neuropathic pain and depression. Methods for treating chronic pain with the described composition are also described.
Claims20
A pharmaceutical formulation comprising ketamine and a bitter taste receptor (TAS2R) response mediating agent, wherein the ketamine is racemic ketamine, S-ketamine, or R-ketamine, and is provided at a concentration between 100 μM and 1 mM, inclusive, the TAS2R response mediating agent is NaOH, and wherein the molar ratio of ketamine to NaOH is from 2:1 to 1:1.
Dependencies are inferred from the claim text.