Replacement heart valves and methods of delivery

A valve prosthesis configured to be deployed within a native heart valve at a native heart valve annulus, the valve prosthesis comprising:

• an expandable frame comprising a proximal end, a distal end, a middle portion between the proximal end and the distal end, and a longitudinal axis extending therethrough, the expandable frame configured to collapse radially for delivery and expand radially upon deployment to an expanded configuration;
• a plurality of circumferentially spaced apart anchors disposed along the distal end of the expandable frame and curved upward towards the proximal end, each anchor being expandable from a collapsed anchor configuration to an expanded anchor configuration, each anchor having a free end positioned radially outwardly from the expandable frame in the expanded anchor configuration;
• a plurality of tips extending from the proximal end of the expandable frame;
• a plurality of first struts positioned radially outwardly when the expandable frame is in the expanded configuration, the plurality of first struts outwardly biasing a fluid flow barrier, the plurality of first struts extending away from the expandable frame in a distal direction along the longitudinal axis, wherein a distal end of each of the plurality of first struts is located distal of the free ends of the anchors when the expandable frame is in the expanded configuration;
• and
• a valve body positioned within an interior of the expandable frame, wherein the valve body comprises a plurality of leaflets configured to allow flow in a first direction and prevent flow in a second opposite direction,
• wherein the distal end of the expandable frame comprises a plurality of distally extending second struts;
• wherein a distal-most end of the plurality of distally extending second struts at the distal end of the expandable frame is located distal of any portion of each of the plurality of circumferentially spaced apart anchors when the expandable frame is in the expanded configuration so as to facilitate engagement with a native leaflet of the native heart valve.