Pharmaceutical composition comprising a cyclic peptide of formula X1-GQRETPEGAEAKPWY-X2 and use for extracorporeal lung treatment

A method of improving the dynamic lung compliance and arterio-venous pO2 difference of a human donor lung extracorporeally, comprising:

• conditioning the human donor lung extracorporeally prior to implantation to improve ventilation performance of the human donor lung, wherein conditioning of the human donor lung comprises treating the human donor lung ex vivo prior to implantation with a nebulized treatment composition comprising a cyclized compound of the amino acid sequence (SEQ ID NO:
• 9) of formula I:
• (I)
• X1-GQRETPEGAEAKPWY-X2
• wherein,
• X1 comprises an amino acid sequence with 1 to 4 members, comprising natural or unnatural amino acids, and
• X2 comprises one amino acid, selected from natural amino acids,
• and wherein the compound is applied into the human donor lung together with ventilating and perfusing said human donor lung.

A method of improving the dynamic lung compliance and arterio-venous pO2 difference of a donor lung, comprising:

• conditioning the donor lung extracorporeally prior to implantation to improve ventilation performance of the donor lung, wherein conditioning of the donor lung comprises treating the donor lung with an aerosol comprising a cyclized compound of the amino acid sequence (SEQ ID NO:
• 9) of formula I:
• (I)
• X1-GQRETPEGAEAKPWY-X2
• wherein,
• X1 comprises an amino acid sequence with 1 to 4 members, comprising natural or unnatural amino acids, and
• X2 comprises one amino acid, selected from natural amino acids,
• and wherein the compound is applied into the donor lung together with ventilating and perfusing said donor lung.