Methods, apparatuses, systems and devices for mobile digital spatial profiling of pathological specimens

A digital spatial profiling (DSP) system comprising:

• a housing or other structure for containing at least one component of the DSP system, comprising:
• a power source;
• an ultraviolet (UV) light source (UVS);
• a visible light source (VLS) for bright field imaging;
• a chamber comprising a slot configured to receive at least a portion of a slide having a tissue sample thereon;
• a personal mobile computing device (PMD) comprising a user interface and a camera sensor, the PMD being arranged relative to the chamber in order to image the tissue sample on the slide within the chamber;
• photomasking means configured to selectively illuminate the tissue sample with UV light from the UVS and/or visible light from the VLS;
• optic means configured to at least one of direct and/or focus the UVS and/or VLS toward at least one of the tissue sample, the chamber, the photomasking means, and the camera sensor;
• and
• processing circuitry configured to
• acquire, via the camera sensor, an image of the tissue sample,
• display, via the user interface of the PMD, the image of the tissue sample,
• receive, via the user interface of the PMD, user input regarding a region of interest (ROD of the tissue sample, and
• illuminate, using the photomasking means, the ROI with UV light,
• wherein the PMD is removably attachable to the housing and/or the chamber.