Transponders and sensors for implantable medical devices and methods of use thereof

An integrated port assembly comprising:

• a chamber configured to receive a fluid;
• wherein an inner surface of the chamber is formed from a material having a density, hardness, or thickness configured to prevent or resist puncturing by a fluid deposition device;
• an electromagnetic wire coil having two ends, each end coupled to an application specific integrated circuit;
• wherein the electromagnetic wire coil shares a central axis with the chamber;
• and
• a port dome covering an opening of the chamber, the port dome configured to seal the chamber;
• wherein the port dome is configured to be penetrable by the fluid deposition device and self-sealing upon removal of the fluid deposition device.