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US 12,000,846 B2Granted
Click-mass spectrometry of alkyne-labeled compounds
AssigneeRheinische Friedrich-Wilhelms-Universitaet Bonn
InventorChristoph Thiele
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Abstract
Nitrogen containing compounds may have formulas (I), (II) and (IV), and such compounds may be suitable for detecting alkyne group containing organic compounds by mass spectrometry. Furthermore, methods may also include synthesizing these compounds, detecting of organic compounds containing the specific compounds, uses of the compounds in mass spectrometry for determining enzyme activity or monitoring the lipid metabolism in a cell, and a kit which contains at least one of these compounds and at least one internal standard.
Claims16
A compound comprising formula (I)
- wherein R1 to R3 are independently selected from substituted or unsubstituted linear C1-C10 alkyl, substituted or unsubstituted branched C3-C10 alkyl, substituted or unsubstituted C3-C10 cycloalkyl, wherein the linear, branched alkyl, or cycloalkyl groups can contain one or more -D atoms, one or more 13C carbon atoms, or combinations thereof;
- or
- wherein R1 is a free valence, and R2 and R3 form a 4 to 7-membered cyclic hydrocarbon ring, wherein the 4 to 7-membered cyclic hydrocarbon ring can contain one or more -D atoms, one or more 13C carbon atoms, or combinations thereof;
- or
- wherein R1 and R2 are each methyl and R3 is ethyl;
- wherein n is 2;
- wherein 1 to 4 X are -D and the remaining X are —H;
- wherein A− is an anion;
- wherein each N in the compound can independently be 15N;
- and wherein each C in the compound can independently be 13C;
- and
- wherein if R1 to R3 are substituted, the substituent is independently selected from -D, —F, —19F, —OH, or —OD.
9 more elements
A compound comprising formula (I)
- wherein R1 and R2 are each methyl and R3 is ethyl;
- wherein n is 2;
- wherein each X is independently selected from —H, -D, —F, —19F, —OH, —OD;
- wherein A− is an anion;
- and
- wherein each N in the compound can independently be 15N;
- and wherein each C in the compound can independently be 13C.
4 more elements
Dependencies are inferred from the claim text.