System and method for protein corona sensor array for early detection of diseases
AssigneeThe Brigham and Women's Hospital, Inc.
InventorsOmid Farokhzad, Morteza Mahmoudi, Claudia Corbo
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Abstract
The present disclosure provides a system comprising a communication interface and computer for assigning a label to the biomolecule fingerprint, wherein the label corresponds to a biological state. The present disclosure also provides a sensor arrays for detecting biomolecules and methods of use. In some embodiments, the sensor arrays are capable of determining a disease state in a subject.
Claims19
A method of distinguishing states of a complex biological sample of a subject using a plurality of particles having surfaces with different physicochemical properties, wherein the method comprises:
- exposing the complex biological sample to the plurality of particles to permit binding of proteins of the complex biological sample to the plurality of particles to allow a plurality of biomolecule coronas to form on the plurality of particles, wherein a pattern of binding of proteins amongst the plurality of particles differs based on the different physicochemical properties of the surfaces of the plurality of particles;
- analyzing the pattern of binding of proteins to define a biomolecule fingerprint representative of proteins that bind to the plurality of particles;
- and
- associating the biomolecule fingerprint with a biological state of the subject.
Dependencies are inferred from the claim text.