Zwitterionic compounds as gas chromatographic column stationary phases
AssigneeIowa State University Research Foundation, Inc.
InventorsJared L. Anderson, Kosuke Kuroda, He Nan
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Abstract
A gas chromatographic (GC) column using a zwitterionic compound and methods of use thereof are disclosed herein. The volatile free acids were observed to strongly retain on these zwitterionic compounds-based columns with excellent peak symmetry. By carefully tuning the structures of these zwitterionic compounds, different selectivity toward volatile free acids was demonstrated. These stationary phases possess a wide working range with thermal stabilities at higher temperatures.
Claims8
A method of chromatographic analysis or separation, the method comprises:
- separating an analyte by a column;
- wherein the column comprises a zwitterionic compound as its stationary phase,
- wherein the zwitterionic compound is a molecule represented by a formula:
- or mixture thereof,
- wherein R1-R5 are independently H, halogen, —NR′R″, —NO2, —COOR′, —CHO, —OR′, —PO3H, —PO3R′, —PO3R′R″, —SO3R′, —SO2, SO3H, —SR′, substituted alkyl group, or unsubstituted alkyl group;
- and wherein R′ and R″ are independently H or an alkyl group;
- and
- wherein at least one of R2 and R1 is a sulfonate or phosphonate, a group containing a —SO3 or P(OR6)O2− group;
- where R6 is H or substituted or unsubstituted alkyl group or anion thereof.
A method for gas chromatographic (GC) separation or analysis of an organic molecule, wherein the method comprises:
- inputting a sample into a gas chromatographic (GC) column,
- wherein the column comprises a zwitterionic compound as its stationary phase;
- wherein the zwitterionic compound is a molecule represented by a formula
- or mixture thereof,
- wherein R1-R5 are independently H, halogen, —NR′R″, —NO2, —COOR′, —CHO, —OR′, —PO3R′, —PO3R′R″, —SO2, —SO3R′, —SR′, or unsubstituted alkyl group;
- and wherein R′ and R″ are independently H or an alkyl group;
- wherein at least one of R2 and R1 is a sulfonate, phosphonate, or a group containing a —SO3″ or —P(OR6)O2− group;
- where R6 is H, or substituted or unsubstituted alkyl group;
- or anion thereof;
- and
- wherein the sample comprises an organic molecule.
Dependencies are inferred from the claim text.