Identification of degradative species
AssigneeSenseonics, Incorporated
InventorsVenkata Velvadapu, Mark Mortellaro
Life of this patent
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Abstract
A sensor (e.g., an optical sensor) that may be implanted within a living animal (e.g., a human) and may be used to measure an analyte (e.g., glucose or oxygen) in a medium (e.g., interstitial fluid, blood, or intraperitoneal fluid) within the animal. The sensor may include a sensor substrate, electrode or housing, an analyte indicator covering at least a portion of the sensor, and one or more probes that identify degradative species in an environment of the sensor.
Claims34
A sensor for measurement of an analyte in a medium within a living animal, the sensor comprising:
- an analyte indicator;
- and
- one or more degradative species probes having absorption and/or emission profiles that are selective for a specific degradative species, wherein the one or more degradative species probes comprise:
- (a) a degradative species probe of Formula I:
- (b) a degradative species probe of Formula II:
- (c) a degradative species probe of Formula IV:
- (d) the degradative species probe of the Formula I and the degradative species probe of the Formula II;
- (e) the degradative species probe of the Formula II and the degradative species probe of the Formula IV;
- (f) the degradative species probe of the Formula I and the degradative species probe of the Formula IV;
- or
- (g) the degradative species probe of the Formula I, the degradative species probe of the Formula II, and the degradative species probe of the Formula IV,
- wherein each R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10 is independently selected from the group consisting of H, C1-C20 alkyl, C1-C20 alkoxy, carboxy, aryl, heteroaryl, polycyclic, alkoxy, halide, SH, aryloxy, alkylthio, amino, substituted amino, alkoxycarbonyl, alkanoylamido, aroylamido, heterocyclocarbonylamido, heteroaroylamido, alkanoyl(alkylsubstituted) amido, aroyl(alkylsubstituted)amido, heteroaroyl(alkylsubstituted)amido, and heterocyclocarbonyl(alkyl substituted)amido.
A method of fabricating a sensor for measurement of an analyte in a medium within a living animal, the method comprising:
- applying an analyte indicator to a sensor such that the applied analyte indicator covers at least a portion of the sensor, wherein the analyte indicator comprises one or more degradative species probes, wherein the degradative species probes have absorption and/or emission profiles that are selective for a specific degradative species, wherein the one or more degradative species probes comprise:
- (a) a degradative species probe of Formula I:
- (b) a degradative species probe of Formula II:
- (c) a degradative species probe of Formula IV:
- (d) the degradative species probe of the Formula I and the degradative species probe of the Formula II;
- (e) the degradative species probe of the Formula II and the degradative species probe of the Formula IV;
- (f) the degradative species probe of the Formula I and the degradative species probe of the Formula IV;
- or
- (g) the degradative species probe of the Formula I, the degradative species probe of the Formula II, and the degradative species probe of the Formula IV,
- wherein each R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10 is independently selected from the group consisting of H, C1-C20 alkyl, C1-C20 alkoxy, carboxy, aryl, heteroaryl, polycyclic, alkoxy, halide, SH, aryloxy, alkylthio, amino, substituted amino, alkoxycarbonyl, alkanoylamido, aroylamido, heterocyclocarbonylamido, heteroaroylamido, alkanoyl(alkylsubstituted) amido, aroyl(alkylsubstituted)amido, heteroaroyl(alkylsubstituted)amido, and heterocyclocarbonyl(alkyl substituted)amido.
Dependencies are inferred from the claim text.