US 12,000,002 B2 · Pre-surgical risk stratification based on PDE4D7 expression and pre-surgical clinical variables

Abstract

The invention relates to a method of pre-surgical risk stratification of a prostate cancer subject, comprising determining a gene expression profile for phosphodiesterase 4D variant 7 (PDE4D7) in a biological sample obtained from the subject, determining gene expression profile, and determining a pre-surgical prognostic risk score for the subject based on the expression based risk score and pre-surgical clinical variables of the subject. This may allow for an improved stratification of the subject in a pre-surgical setting that may result in better primary treatment decisions. For instance, the pre-surgical prognostic risk score may allow to make better recommendation on whether to select active surveillance vs. active intervention, e.g., radical prostatectomy, for certain sub-populations of prostate cancer patients.

Claims13

Dependent claims

A method of risk stratification of a prostate cancer subject, comprising:

obtaining a biological sample from the prostate cancer subject, wherein the prostate cancer subject has not undergone prostate cancer surgery;
determining a gene expression profile for phosphodiesterase 4D variant 7 (PDE4D7) in the biological sample obtained from the subject;
determining an expression based risk score for the subject based on the gene expression profile;
determining a prognostic risk score for the subject based on the expression based risk score and clinical variables of the subject;
and
administering a primary treatment for the subject based on the prognostic risk score, wherein the primary treatment is selected from the group consisting of:
(i) at least a partial prostatectomy;
and (ii) an active therapy selected from radiation treatment, hormone therapy, chemotherapy, and a combination thereof.

5 more elements

Dependencies are inferred from the claim text.

Pre-surgical risk stratification based on PDE4D7 expression and pre-surgical clinical variables

Life of this patent

Pre-surgical risk stratification based on PDE4D7 expression and pre-surgical clinical variables

Life of this patent

Abstract

Claims13