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AssigneeNational Cheng Kung University
InventorsNan-Haw Chow, Yi-Wen Wang, Yih-Lin Tuan, Yao-Lung Kuo
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The present invention discloses a targeted therapy composition and a method for suppressing breast cancer cell proliferation, migration or invasion by administrating the targeted therapy composition to a subject in need thereof. The composition comprises a type 3 epithelial membrane proteins (EMP3) targeted inhibitor. The breast cancer cells are characterized by upregulation of EMP3, EGFR, HER2, HER3, HR, or downregulation of HER4 gene expression. EMP3-targeting oligonucleotide or nuclease is administrated upon the breast cancer cells so as to degrade EMP3-coding DNA or mRNA, and to suppress breast cancer cell proliferation, migration or invasion.
A method for suppressing breast cancer cell proliferation, migration or invasion, comprising administrating a targeted therapy composition comprising an effective dosage of EMP3-targeting inhibitor to a subject in need thereof;
A method for suppressing breast cancer cell proliferation, migration or invasion, comprising administrating a targeted therapy composition comprising an effective dosage of EMP3-targeting inhibitor to a subject in need thereof;
Dependencies are inferred from the claim text.