Peptide inhibitors of CRISPR-Cas9
AssigneeNational Technology & Engineering Solutions of Sandia, LLC
InventorsBrooke Nicole Harmon, Yooli Kim Light, Mary Bao Tran-Gyamfi, Joseph S. Schoeniger, Edwin A. Saada, Kenneth L. Sale
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Abstract
Specific and broad-spectrum inhibitory peptides to CRISPR Cas9 variants (SpyCas9, SauCas9, and CjeCas9) are disclosed. A method of making and using these peptides with therapeutic CRISPR Cas9 (to improve desired targeting) or against harmful CRISPR Cas9 components (already active in a patient) is also disclosed. The peptides combined with a delivery system is also disclosed.
Claims18
An agent selected from the group consisting of:
- an amino acid sequence having at least 90% sequence identity to any one of SEQ ID NOs:
- 1, 3-10, and 12-28 and combinations thereof;
- wherein the sequence identity is calculated over a full length of the amino acid sequence.
A composition comprising an amino acid sequence having at least 90% sequence identity to any one of SEQ ID NOs:
- 1, 3-10, and 12-28;
- and a pharmaceutically acceptable excipient;
- wherein the sequence identity is calculated over a full length of the amino acid sequence.
Dependencies are inferred from the claim text.