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US 11,999,789 B2Granted
Humanized antibodies to TNF-like ligand 1A (TL1A) and uses thereof
AssigneesPrometheus Biosciences, Inc., Cedars-Sinai Medical Center
InventorsJeffry D. Watkins, Cindy T. Dickerson, Rafael Rojas, Matthew Reissman, Patricia McNeeley, Janine Bilsborough, Bradley Henkle, Stephan R. Targan
Life of this patent
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Abstract
Described herein are humanized anti-TL1A antibodies and pharmaceutical compositions for the treatment of inflammatory bowel disease (IBD), such as Crohn's Disease (CD) and ulcerative colitis (UC).
Claims7
An antibody or antigen binding fragment thereof that binds to tumor necrosis factor ligand 1A (TL1A), wherein the antibody or antigen binding fragment thereof comprises:
- (a) a heavy chain variable region comprising the amino acid sequence of SEQ ID NO:
- 104 and (b) a light chain variable region comprising the amino acid sequence of SEQ ID NO:
- 201.
An antibody that binds to tumor necrosis factor ligand 1A (TL1A), wherein the antibody comprises:
- (a) a heavy chain comprising the amino acid sequence of SEQ ID NO:
- 505 and (b) a light chain comprising the amino acid sequence of SEQ ID NO:
- 514.
Dependencies are inferred from the claim text.