Binding molecule specific for Lrig-1 protein and use thereof

A binding molecule which specifically binds to leucine-rich and immunoglobulin-like domains 1(Lrig-1) protein, wherein the binding molecule is selected from the group consisting of the following (a) to (d):

• (a) a binding molecule comprising a heavy chain variable region that contains the heavy chain CDR1 represented by SEQ ID NO:
• 5, the heavy chain CDR2 represented by SEQ ID NO:
• 6, and the heavy chain CDR3 represented by SEQ ID NO:
• 7;
• and a light chain variable region that contains the light chain CDR1 represented by SEQ ID NO:
• 8, the light chain CDR2 represented by SEQ ID NO:
• 9, and the light chain CDR3 represented by SEQ ID NO:
• 10;
• (b) a binding molecule comprising a heavy chain variable region that contains the heavy chain CDR1 represented by SEQ ID NO:
• 13, the heavy chain CDR2 represented by SEQ ID NO:
• 14, and the heavy chain CDR3 represented by SEQ ID NO:
• 15;
• and a light chain variable region that contains the light chain CDR1 represented by SEQ ID NO:
• 16, the light chain CDR2 represented by SEQ ID NO:
• 17, and the light chain CDR3 represented by SEQ ID NO:
• 18;
• (c) a binding molecule comprising a heavy chain variable region that contains the heavy chain CDR1 represented by SEQ ID NO:
• 21, the heavy chain CDR2 represented by SEQ ID NO:
• 22, and the heavy chain CDR3 represented by SEQ ID NO:
• 23;
• and a light chain variable region that contains the light chain CDR1 represented by SEQ ID NO:
• 24, the light chain CDR2 represented by SEQ ID NO:
• 25, and the light chain CDR3 represented by SEQ ID NO:
• 26;
• and
• (d) a binding molecule comprising a heavy chain variable region that contains the heavy chain CDR1 represented by SEQ ID NO:
• 29, the heavy chain CDR2 represented by SEQ ID NO:
• 30, and the heavy chain CDR3 represented by SEQ ID NO:
• 31;
• and a light chain variable region that contains the light chain CDR1 represented by SEQ ID NO:
• 32, the light chain CDR2 represented by SEQ ID NO:
• 33, and the light chain CDR3 represented by SEQ ID NO:
• 34,
• wherein the binding molecule is antibody a bispecific antibody or fragment thereof.