VEGF-binding protein for blockade of angiogenesis
AssigneesChildren's Medical Center Corporation, The General Hospital Corporation, President and Fellows of Harvard College
InventorsBob Carter, Jeng-Shin Lee, Szofia S. Bullain, Richard C. Mulligan
Life of this patent
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Abstract
Provided are chimeric VEGF-binding proteins and nucleic acids (e.g., a vector) encoding chimeric VEGF-binding proteins, methods and host cells for producing these proteins and nucleic acids, and pharmaceutical compositions containing these proteins and nucleic acids. Also provided are methods of treating an angiogenic disease or disorder that include administering at least one of the chimeric VEGF-binding proteins or at least one of the nucleic acids (e.g., a vector) encoding a chimeric VEGF-binding protein.
Claims17
A method of treating an angiogenic disease or disorder, comprising administering to a subject in need thereof a vector comprising a polynucleotide encoding a chimeric VEGF-binding protein comprising the amino acid sequence of SEQ ID NO:
- 3.
A method of reducing blood vessel formation in a tumor in a subject, the method comprising administering to a subject in need thereof a vector comprising a polynucleotide encoding a chimeric VEGF-binding protein comprising the amino acid sequence of SEQ ID NO:
- 3.
Dependencies are inferred from the claim text.