Peptides and nanoparticle formulations thereof
AssigneeUniversity of Bradford
InventorsMohamed El-Tanani, Paul McCarron, Ahmed Faheem
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Abstract
The present invention relates to peptides, methods for production of the same, nanoparticle formulations of the same and the use of these new peptides and nanoparticle formulations as inhibitors of protein-protein interactions, in particular for application in the treatment of diseases associated with overexpression of the RAN gene.
Claims16
A method for inhibiting the binding of regulator chromosome condensation 1 (RCC1) to GDP bound Ras-related nuclear proteins (RanGDP) in a subject in need thereof, wherein one or more cells of the subject overexpress Ras-related nuclear protein (RAN), comprising administering to the subject a therapeutically effective amount of a peptide comprising the amino acid sequence of SEQ ID NO:5 to inhibit the binding of RCC1 to RanGDP in the one or more cells overexpressing RAN.
A method for treating triple-negative breast cancer in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a peptide comprising the amino acid sequence of SEQ ID NO:
- 5.
A method for treating non-small cell lung cancer in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a peptide comprising the amino acid sequence of SEQ ID NO:
- 5.
Dependencies are inferred from the claim text.