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US 11,999,758 B2Granted
Inhibitors of the YAP/TAZ-TEAD interaction and their use in the treatment of cancer
AssigneeInventiva
InventorsMartine Barth, Sylvie Contal, Jean-Louis Junien, Christine Massardier, Christian Montalbetti, Anne Soude
Life of this patent
Estimating the term…
Abstract
The invention relates to compounds of formula (I): wherein R1, R2, R3, R4, R5 and are as defined in the description.
Claims19
A compound of formula (I):
- wherein:
- is a substituted or unsubstituted N-containing monocyclic, bicyclic or tricyclic heteroraryl;
- R1 is H, an alkyl optionally substituted with one or two groups R6 or an aryl optionally substituted with one or more groups R6;
- R2 is H or alkyl;
- or
- R1 and R2 are bound together to form a 5- or 6-membered heterocycle;
- R3 and R4 are each independently H or an alkyl optionally substituted with one or two groups R6;
- or
- R3 and R4 are bound together to form a 5- to 8-membered heterocycle;
- R5 is H, a halogen, an alkyl optionally substituted with 1 or 2 groups R6, or an alkoxy optionally substituted with 1 or 2 groups R6;
- or
- R4 and R5 are bound together to form a 5- to 7-membered heterocyle;
- R6 is hydroxy, alkoxy, —NR15R16, —CO—Y—R17, —CN, —CF3, or aryl;
- R15 and R16 are each independently H, alkyl, —CO-alkyl or form together with the nitrogen atom a 3- to 6-membered cyclic group;
- Y is —O— or —NR18—;
- R17 is H or alkyl;
- and
- R18 is H, alkyl or hydroxyalkyl;
- provided that when R3 is H and R4 and R5 are bound together to form a 5-membered heterocycle, then R1 is not H;
- or a pharmaceutically acceptable salt thereof.
17 more elements
Dependencies are inferred from the claim text.