US 11,999,745 B2Granted

Pharmaceutical compounds

AssigneesHeptares Therapeutics Limited, Allergan Pharmaceuticals Therapeutics International Limited

InventorsCharlotte Fieldhouse, Miles Stuart Congreve

Life of this patent

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Abstract

This invention relates to compounds that are agonists of the muscarinic M1 and M4 receptor and which are useful in the treatment of diseases mediated by the muscarinic M1 and/or M4 receptors. Also provided are pharmaceutical compositions containing the compounds and the therapeutic uses of the compounds. Compounds provided are of formula (1): and salts thereof.

Claims31

Dependent claims

A compound of formula (1):

or a salt thereof.

Dependencies are inferred from the claim text.

Facts

Application: 17/874,564Filed 27 Jul 2022 · continuation
Priority: GB 202019118 Dec 2020
Published: US 2022/0380379 A11 Dec 2022
Granted: 4 Jun 2024
Term ends: Not estimatedThe source records don’t support an estimate.

Classification8 codes

C07D 451/02
Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring…:…
C07D 487/10
In which the condensed system contains two hetero rings: spiro-condensed systems
A61P 25/18
Drugs for disorders of the nervous system: antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
A61P 25/28
Drugs for disorders of the nervous system: for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents,…

Family

PCT/GB2021/053372Parent of this continuation · filed 20 Dec 2021
US 2022/0380379 A1Pre-grant publication · published 1 Dec 2022
US 11,999,745 B2This patent

From the US filing history. Foreign family members aren’t listed.

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