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US 11,999,743 B2Granted
Crystalline form of (S)-7-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetra-hydropyrazolo[1,5-a]pyrimidine-3-carboxamide, preparation, and uses thereof
AssigneeBeiGene Switzerland GmbH
InventorsZhiwei Wang, Yunhang Guo, Gongyin Shi
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Abstract
The present invention relates to a crystalline form of (S)-7-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetra-hydropyrazolo[1,5-a]pyrimidine-3-carboxamide for inhibiting Btk, methods of preparation thereof and pharmaceutical compositions, and use of the crystalline form above in the treatment of a disease, or in the manufacturing of a medicament for the treatment of a disease.
Claims27
An amorphous form of Compound 1,
- wherein the amorphous form has an enantiomeric excess value of at least 90%.
A lyophilized amorphous form of Compound 1,
Dependencies are inferred from the claim text.