Antimicrobials methods of making and using the same

A compound of Formula (II):

• or a tautomer thereof or a pharmaceutically acceptable salt of the compound or tautomer wherein:
• R1 is selected from the group consisting of H and halo;
• R2 is selected from the group consisting of H, halo, C1-6 alkyl, C1-4 haloalkyl, and ORa1;
• R3 is selected from the group consisting of H, C1-6 alkyl, C1-4 haloalkyl, and C(O)ORa1;
• W is selected from the group consisting of N and CR4;
• R5 is halo and R4 is selected from the group consisting of halo, S(C1-4 alkyl), and 6-membered heterocycloalkyl;
• R6 is selected from the group consisting of H, C1-6 alkyl, C3-5 cycloalkyl, and C2-6 alkenyl wherein the C1-6 alkyl is optionally substituted with a substituent selected from the group consisting of ORa3, SRa3, and NRc3Rd3;
• R7A is selected from the group consisting of H, C1-6 alkyl, C1-4 haloalkyl, and C2-6 alkenyl, wherein the C1-6 alkyl is optionally substituted with a substituent selected from the group consisting of ORa3 and SRa3;
• R7B is H;
• or
• R7A and R7B together with the carbon atom to which they are attached form a group selected from the group consisting of oxo, and C3-6 cycloalkyl;
• or
• R6 and R7A together with the carbon atoms to which they are attached and the X atom connecting the two carbon atoms form a 5-to 6-membered heterocycloalkyl containing 1-3 heteroatoms selected from N, O and S;
• X is selected from the group consisting of O and NR8;
• R8 is selected from the group consisting of H, C1-6 alkyl, and C1-4 haloalkyl, wherein the C1-6 alkyl is optionally substituted with R8A;
• R8A is selected from the group consisting of 5-to 6-membered heteroaryl, and ORa3, wherein the 5-to 6-membered heteroaryl is optionally substituted with one or two C1-6 alkyl;
• R9 is selected from the group consisting of H, C2-4 alkenyl, C1-4 haloalkyl and C1-4 alkyl optionally substituted with a substituent selected from the group consisting of amino, C1-4 alkoxy, C3-5 cycloalkyl, and 3- to 6-membered heterocycloalkyl;
• R10 is selected from the group consisting of H and C2-6 alkenyl;
• RA is selected from the group consisting of H and C1-6 alkyl;
• L is selected from the group consisting of C1-6 alkyl and C2-6 alkenyl, wherein the C1-6 alkyl is optionally substituted with 1, 2, or 3 substituents independently selected from halo OR′, and SRa4;
• R11 is selected from the group consisting of H, C1-6 alkyl, C3-5 cycloalkyl, C1-4 haloalkyl, and C2-6 alkenyl, wherein the C1-6 alkyl is optionally substituted with 1, 2, or 3 substituents independently selected from group consisting of CN, ORa5, SRa5, C(O)NRc5Rd5, Nc5Rd5 and S(O)2Rb5;
• R12 is selected from the group consisting of H and C1-6 alkyl;
• or
• R11 and R12 together with the carbon atom to which they are attached form a C3-5 cycloalkyl;
• R13 is selected from the group consisting of H, halo, and C1-6 alkyl;
• R14 is selected from the group consisting of H, halo, and C1-6 alkyl;
• and
• RB is selected from the group consisting of H and C(═NRe5)Rb5;
• or
• R11 and RB together with the carbon atom to which R11 is attached and the nitrogen atom to which RB is attached form a 5- to 6-membered heterocycloalkyl containing 1-3 heteroatoms selected from the group consisting of N, O and S, wherein the 5- to 6-membered heterocycloalkyl is optionally substituted with oxo;
• each Ra1, Ra3, Ra4, Ra5, Rb5, Rc3, Rd3, Rc5, and Rd5 is independently selected from the group consisting of H, C1-6 alkyl, C1-4 haloalkyl, and 5-membered heteroaryl;
• and Re5 is selected from the group consisting of H and C1-4 alkyl.