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US 11,999,737 B2Granted
Kinase inhibitors and related methods of use
AssigneeDuke University
InventorsTimothy A. J. Haystead, David A. Carlson, Douglas H. Weitzel, Justin A. MacDonald, Michael P. Walsh
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Abstract
The present disclosure is directed to compounds that may selectively inhibit Death Associated Protein Kinases (DAPKs) as well as PIM kinases. The compounds can be used in methods of treating various disorders, including cancers.
Claims8
A compound of formula (II), or a pharmaceutically acceptable salt thereof:
- wherein:
- R2 is selected from the group consisting of C1-C6 alkyl, substituted aryl and optionally substituted heteroaryl;
- R3 is hydrogen;
- R4 and R5 together form an oxo group;
- R6 is selected from the group consisting of hydrogen and —(CRaRb)n—X;
- R7 is selected from the group consisting of hydrogen and —(CRaRb)n—X;
- each Ra and Rb is independently selected from the group consisting of hydrogen and C1-C4 alkyl;
- n is 1, 2, 3, 4, 5 or 6;
- each X is independently selected from the group consisting of optionally substituted aryl, optionally substituted heteroaryl, —ORc, —CORd, —COORe, —CON(Rf)(Rg), —CN;
- each Rc is independently selected from the group consisting of hydrogen, C1-C4 alkyl, and —(CH2)m—Y wherein m is 1, 2 or 3 and Y is selected from the group consisting of —OH, —O(C1-C4-alkyl), —COORe and —CON(Rf)(Rg);
- each Rd is independently selected from the group consisting of optionally substituted aryl, optionally substituted heteroaryl and —(CH2)p—Z wherein p is 1, 2 or 3 and Z is selected from the group consisting of —OH, —O(C1-C4-alkyl), —COORe and —CON(Rf)(Rg);
- and
- each Re, Rf and Rg is independently selected from the group consisting of hydrogen and C1-C4 alkyl.
10 more elements
Dependencies are inferred from the claim text.