AKT1 modulators

A compound having the structure of Formula (Ib), or a pharmaceutically acceptable salt or solvate thereof:

• wherein:
• Z1 is N, C—H, or C—R3;
• Z2 is N, C—H, or C—R4;
• Ar is selected from:
• X1 is Nor C—R7;
• X2 is N or C—R7;
• X3 is N or C—R7;
• X4 is N or C—R7;
• Y is O, S, or N—R9;
• R1 is selected from optionally substituted aryl, or optionally substituted heteroaryl;
• R2 is selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted aryl, or optionally substituted heteroaryl;
• R3 is selected from optionally substituted C1-C6 alkyl, or optionally substituted aryl;
• R4 is selected from optionally substituted C1-C6 alkyl, or optionally substituted aryl;
• R5 and R6 are each independently hydrogen, deuterium, halogen, —OH, or optionally substituted C1-C6 alkyl;
• or R5 and R6 together form an oxo;
• or R5 and R6 join together to form a carbocycle or heterocycle;
• each R7 is independently selected from hydrogen, deuterium, halogen, —OH, —SH, optionally substituted C1-C6 alkoxy, —S-(optionally substituted C1-C6 alkyl), —CN, optionally substituted C1-C6 alkyl, and optionally substituted aryl;
• L is a divalent radical selected from
• wherein the asterisk (*) indicates the bond to the —(C(O))q-Ar group:
• R8 is hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C3-C7 cycloalkyl, or optionally substituted heterocyclyl;
• R9 is hydrogen, or optionally substituted C1-C6 alkyl;
• m is 0, 1, or 2;
• n is 1, 2, or 3;
• and
• q is 0 or 1.