Small molecule inhibition of transcription factor SALL4 and uses thereof

A compound having a structure of Formula I or a pharmaceutically acceptable salt thereof:

• wherein
• Z is N;
• R1 is optionally substituted C5 or C6-cycloalkyl, optionally substituted heterocyclyl, naphthalenyl substituted with one or more groups selected from hydroxyl and nitro,
• optionally substituted oxazolyl, optionally substituted benzoisoxazolyl, optionally substituted indazolyl, optionally substituted azaindolyl, optionally substituted benzothiazolyl, optionally substituted thiazolyl, or optionally substituted carbazolyl;
• and
• R2 is optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted heterocyclyl, optionally substituted aryl, or optionally substituted heteroaryl.