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US 11,999,722 B2Granted
Disubstituted pyrazole compounds
AssigneeEli Lilly and Company
InventorsDavid Andrew Coates, Timothy Barrett Durham, Richard Duane Johnston, Steven Marc Massey, Patrick Gianpietro Spinazze, Douglas Richard Stack, James Lee Toth
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Abstract
The present invention provides a compound of Formula I. or a pharmaceutically acceptable salt thereof, and the use of compounds of Formula I for treating metabolic conditions, such as type 2 diabetes mellitus, heart failure, diabetic kidney disease, and non-alcoholic steatohepatitis.
Claims7
A method of treating chronic kidney disease in a patient, comprising administering to a patient in need of such treatment an effective amount of a compound of the formula:
- wherein
- X is N, or C substituted with CN;
- R1 is selected from:
- H,
- R2 and R3 are both H, or one is H and the other is OH;
- R4, R5, R6, R7 and R9 are independently H or CH3;
- R8 is H, CH3, CH2CH2OH, C(═O)CH2NH2, or C(═O)CH3;
- and
- R10 is OH or NH2;
- or a pharmaceutically acceptable salt thereof.
7 more elements
Dependencies are inferred from the claim text.