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US 11,999,720 B2Granted
Pyrazolylacylpyrazoline compounds and method for treating pain
AssigneesThe Trustees of Indiana University, The United States Government as represented by the Department of Veterans Affairs
InventorsSamy Meroueh, Fletcher A. White, Alexander G. Obukhov
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Abstract
This invention relates to pyrazolylacylpyrazoline compounds or pharmaceutically acceptable salts thereof, and for the use of the compounds to treat neurological disorders.
Claims12
A compound of Formula (1)
- wherein
- R1 is selected from the group consisting of (C1-C4 alkyl)-CO2H, —CO2H substituted phenyl, and tetrazole substituted phenyl;
- R2 is selected from the group consisting of phenyl, methoxy substituted phenyl, and pyridinyl;
- R3 is selected from the group consisting of (C1-C3 alkyl) substituted phenyl and halo substituted phenyl;
- and
- R4 is selected from the group consisting of alkoxy substituted phenyl and pyridyl substituted phenyl;
- with the proviso that the compound of Formula (1) is not
- or a pharmaceutically acceptable salt thereof.
5 more elements
A compound selected from the group consisting of
- or a pharmaceutically acceptable salt thereof.
A compound of Formula (1)
- wherein:
- R1 is selected from the group consisting of —CO2H substituted phenyl, and tetrazole substituted phenyl;
- R2 is selected from the group consisting of phenyl, methoxy substituted phenyl and pyridinyl;
- R3 is (C1-C3 alkyl) substituted phenyl and halo substituted phenyl;
- and
- R4 is alkoxy substituted phenyl;
- or a pharmaceutically acceptable salt thereof.
4 more elements
Dependencies are inferred from the claim text.