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US 11,999,713 B2Granted
Methionine adenosyltransferase 2a (MAT2A) inhibitors and uses thereof
AssigneeInsilico Medicine IP Limited
InventorsChiachun Chen, Xiao Ding, Xiaosong Liu, Feng Ren, Hailong Wang
Life of this patent
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Abstract
Described herein are MAT2A inhibitors and pharmaceutical compositions comprising said inhibitors. The subject compounds and compositions are useful for the treatment of a disease or disorder associated with MAT2A.
Claims20
A compound of Formula (I) or Formula (II), or a pharmaceutically acceptable salt thereof:
- wherein:
- is selected from pyridyl, pyrazinyl, pyrimidyl, and pyridazinyl;
- Z1 is CR7;
- Z2 is CR9;
- Z3 is CR6;
- Z4 is CR6a;
- X is —N(R4)—;
- Y is —N(R4a);
- R1 is hydrogen;
- R1a and R1b are hydrogen;
- R2 and R3 are each independently selected from hydrogen and C1-6alkyl;
- or R2 and R3, together with the carbon to which they are attached, form a C3-6cycloalkyl;
- R4 is hydrogen;
- R4a is hydrogen;
- R6 is selected from hydrogen, halogen, and —OR10;
- R6a is selected from hydrogen and —OR10;
- R7 is hydrogen;
- R8 is selected from hydrogen, halogen, and C1-6haloalkyl;
- R9 is hydrogen;
- each R10 is independently selected from hydrogen, C1-6alkyl, and C1-6haloalkyl;
- each R14 is independently C1-6alkyl;
- m is 0, 1, or 2;
- and
- n is 1.
21 more elements
A method of treating cancer in a mammal in need thereof, comprising administering to the mammal a compound of Formula (I) or Formula (II), or a pharmaceutically acceptable salt thereof:
- wherein:
- is selected from pyridyl, pyrazinyl, pyrimidyl, and pyridazinyl;
- Z1 is CR7;
- Z2 is CR9;
- Z3 is CR6;
- Z4 is CR6a;
- X is —N(R4)—;
- Y is —N(R4a)—;
- R1 is hydrogen;
- R1a and R1b are hydrogen;
- R2 and R3 are each independently selected from hydrogen and C1-6alkyl;
- or R2 and R3, together with the carbon to which they are attached, form a C3-6cycloalkyl;
- R4 is hydrogen;
- R4a is hydrogen;
- R6 is selected from hydrogen, halogen, and —OR10;
- R6a is selected from hydrogen and —OR10;
- R7 is hydrogen;
- R8 is selected from hydrogen, halogen, and C1-6haloalkyl;
- R9 is hydrogen;
- each R10 is independently selected from hydrogen, C1-6alkyl, and C1-6haloalkyl;
- each R14 is independently C1-6alkyl;
- m is 0, 1, or 2;
- and
- n is 1.
21 more elements
Dependencies are inferred from the claim text.